Anti-ROCK1 monoclonal antibody

Pre-made anti-ROCK1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to ROCK1/ROCK1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T51282-Ab-1/ GM-Tg-hg-T51282-Ab-2Anti-Human ROCK1 monoclonal antibodyHuman
GM-Tg-rg-T51282-Ab-1/ GM-Tg-rg-T51282-Ab-2Anti-Rat ROCK1 monoclonal antibodyRat
GM-Tg-mg-T51282-Ab-1/ GM-Tg-mg-T51282-Ab-2Anti-Mouse ROCK1 monoclonal antibodyMouse
GM-Tg-cynog-T51282-Ab-1/ GM-Tg-cynog-T51282-Ab-2Anti-Cynomolgus/ Rhesus macaque ROCK1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T51282-Ab-1/ GM-Tg-felg-T51282-Ab-2Anti-Feline ROCK1 monoclonal antibodyFeline
GM-Tg-cang-T51282-Ab-1/ GM-Tg-cang-T51282-Ab-2Anti-Canine ROCK1 monoclonal antibodyCanine
GM-Tg-bovg-T51282-Ab-1/ GM-Tg-bovg-T51282-Ab-2Anti-Bovine ROCK1 monoclonal antibodyBovine
GM-Tg-equg-T51282-Ab-1/ GM-Tg-equg-T51282-Ab-2Anti-Equine ROCK1 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T51282-Ab-1/ GM-Tg-hg-T51282-Ab-2; GM-Tg-rg-T51282-Ab-1/ GM-Tg-rg-T51282-Ab-2;
GM-Tg-mg-T51282-Ab-1/ GM-Tg-mg-T51282-Ab-2; GM-Tg-cynog-T51282-Ab-1/ GM-Tg-cynog-T51282-Ab-2;
GM-Tg-felg-T51282-Ab-1/ GM-Tg-felg-T51282-Ab-2; GM-Tg-cang-T51282-Ab-1/ GM-Tg-cang-T51282-Ab-2;
GM-Tg-bovg-T51282-Ab-1/ GM-Tg-bovg-T51282-Ab-2; GM-Tg-equg-T51282-Ab-1/ GM-Tg-equg-T51282-Ab-2
Products NameAnti-ROCK1 monoclonal antibody
Formatmab
Target NameROCK1
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-ROCK1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T51282-Ag-1Recombinant multi-species ROCK1/ P160ROCK/ ROCK-I protein
    ORF Viral VectorvGMLV000212human ROCK1 Lentivirus particle
    ORF Viral VectorpGMLV000212human ROCK1 Lentivirus plasmid


    Target information

    Target IDGM-T51282
    Target NameROCK1
    Gene ID6093,19877,81762,698223,480181,101092552,785911,100034056
    Gene Symbol and Synonyms1110055K06Rik,P160ROCK,ROCK-I,ROCK1
    Uniprot AccessionQ13464,Q63644,Q8MIT6
    Uniprot Entry NameROCK1_HUMAN,ROCK1_RAT,ROCK1_BOVIN
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000067900
    Target ClassificationKinase, Tumor-associated antigen (TAA)

    The target: ROCK1, gene name: ROCK1, also named as P160ROCK, ROCK-I. This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.