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Anti-HDAC4 monoclonal antibody
Pre-made anti-HDAC4 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to HDAC4/HDAC4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T63816-Ab-1/ GM-Tg-hg-T63816-Ab-2 | Anti-Human HDAC4 monoclonal antibody | Human |
| GM-Tg-rg-T63816-Ab-1/ GM-Tg-rg-T63816-Ab-2 | Anti-Rat HDAC4 monoclonal antibody | Rat |
| GM-Tg-mg-T63816-Ab-1/ GM-Tg-mg-T63816-Ab-2 | Anti-Mouse HDAC4 monoclonal antibody | Mouse |
| GM-Tg-cynog-T63816-Ab-1/ GM-Tg-cynog-T63816-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HDAC4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T63816-Ab-1/ GM-Tg-felg-T63816-Ab-2 | Anti-Feline HDAC4 monoclonal antibody | Feline |
| GM-Tg-cang-T63816-Ab-1/ GM-Tg-cang-T63816-Ab-2 | Anti-Canine HDAC4 monoclonal antibody | Canine |
| GM-Tg-bovg-T63816-Ab-1/ GM-Tg-bovg-T63816-Ab-2 | Anti-Bovine HDAC4 monoclonal antibody | Bovine |
| GM-Tg-equg-T63816-Ab-1/ GM-Tg-equg-T63816-Ab-2 | Anti-Equine HDAC4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T63816-Ab-1/ GM-Tg-hg-T63816-Ab-2; GM-Tg-rg-T63816-Ab-1/ GM-Tg-rg-T63816-Ab-2; GM-Tg-mg-T63816-Ab-1/ GM-Tg-mg-T63816-Ab-2; GM-Tg-cynog-T63816-Ab-1/ GM-Tg-cynog-T63816-Ab-2; GM-Tg-felg-T63816-Ab-1/ GM-Tg-felg-T63816-Ab-2; GM-Tg-cang-T63816-Ab-1/ GM-Tg-cang-T63816-Ab-2; GM-Tg-bovg-T63816-Ab-1/ GM-Tg-bovg-T63816-Ab-2; GM-Tg-equg-T63816-Ab-1/ GM-Tg-equg-T63816-Ab-2 |
| Products Name | Anti-HDAC4 monoclonal antibody |
| Format | mab |
| Target Name | HDAC4 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-HDAC4 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T63816-Ag-1 | Recombinant multi-species HDAC4/ AHO3/ BDMR protein |
| ORF Viral Vector | pGMLPm005100 | mouse Hdac4 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005100 | mouse Hdac4 Lentivirus particle |
Target information
| Target ID | GM-T63816 |
| Target Name | HDAC4 |
| Gene ID | 9759,208727,363287,710797,607662,101093384,517559,100067014 |
| Gene Symbol and Synonyms | 4932408F19Rik,AHO3,BDMR,HA6116,HD4,HDAC-4,HDAC-A,HDAC4,HDACA,NEDCHF,NEDCHID |
| Uniprot Accession | P56524,Q99P99 |
| Uniprot Entry Name | HDAC4_HUMAN,HDAC4_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000068024 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: HDAC4, gene name: HDAC4, also named as AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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