Bovine p-tau202 and 205 antibody and antigen (recombinant protein)

Diagnostic anti-Bovine p-tau202 and 205 antibodies pairs and antigen for animal health (animal Bovines/Cattle Alzheimer Disease(AD)) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Target products collectionGo to Ruminants disease testing products collection >>


Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-BOV-p-tau202-205-Ag01Bovine p-tau202 and 205$3090.00
GMP-BOV-p-tau202-205-Ab01Anti-Bovine p-tau202 and 205 mouse monoclonal antibody (mAb)$3090.00
GMP-BOV-p-tau202-205-Ab02Anti-Bovine p-tau202 and 205 mouse monoclonal antibody (mAb)$3090.00
GMP-BOV-p-tau202-205-Ab03Anti-Bovine p-tau202 and 205 human monoclonal antibody (mAb)$3090.00
GMP-BOV-p-tau202-205-Ab04Anti-Bovine p-tau202 and 205 human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-BOV-p-tau202-205-Ag01
Product NameBovine p-tau202 and 205
Target/BiomarkerBovine p-tau202 and 205
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Bovine p-tau202 and 205 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in p-tau202 and 205 level test of animal Bovines/Cattle with Alzheimer Disease(AD).
TagHis
Reconized/Reactive SpecicsBovine p-tau202 and 205
Product descriptionRecombinant Bovine p-tau202 and 205 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-BOV-p-tau202-205-Ab01,GMP-BOV-p-tau202-205-Ab02
Target/BiomarkerBovine p-tau202 and 205
Product NameAnti-Bovine p-tau202 and 205 mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Bovine p-tau202 and 205 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bovine p-tau202 and 205 antibodies in Bovine p-tau202 and 205 level test of animal Bovines/Cattle with Alzheimer Disease(AD).
Product descriptionAnti-Bovine p-tau202 and 205 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bovine p-tau202 and 205 antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-BOV-p-tau202-205-Ab03,GMP-BOV-p-tau202-205-Ab04
Target/BiomarkerBovine p-tau202 and 205
Product NameAnti-Bovine p-tau202 and 205 human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Bovine p-tau202 and 205 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bovine p-tau202 and 205 antibodies in Bovine p-tau202 and 205 level test of animal Bovines/Cattle with Alzheimer Disease(AD).
Product descriptionAnti-Bovine p-tau202 and 205 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    Bovine p-tau202 and p-tau205, the phosphorylated Tau Proteins unique to cattle, represent a vital aspect of bovine neurobiology. At their core, they are Tau proteins that have undergone specific biochemical modifications – phosphorylation – at residues 202 and 205. Under normal circumstances, Tau proteins in cattle play a pivotal role in stabilizing microtubules, essential for axonal stability and intracellular transport within neuronal cells.

    However, in the context of neurodegenerative diseases, the narrative takes a different course. Phosphorylation events can trigger the misfolding and aggregation of Tau proteins, and in cattle, p-tau202 and p-tau205 tend to aggregate and form neurofibrillary tangles (NFTs) within neural tissues.

    These NFTs, akin to those observed in human neurodegenerative diseases like Alzheimer's, represent a pathological signature of various bovine neurodegenerative conditions. The accumulation of p-tau202 and p-tau205 in NFTs contributes to progressive neuronal dysfunction, altered behavior, and motor disturbances observed in conditions such as bovine spongiform encephalopathy (BSE) and other neurocognitive disorders in cattle.



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