Canine p-tau181 antibody and antigen (recombinant protein)

Diagnostic anti-Canine p-tau181 antibodies pairs and antigen for animal health (animal Dog/Canine Alzheimer Disease(AD)) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Target products collectionGo to Companion Animal disease testing products collection >>


Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-CAN-p-tau181-Ag01Canine p-tau181$3090.00
GMP-CAN-p-tau181-Ab01Anti-Canine p-tau181 mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-p-tau181-Ab02Anti-Canine p-tau181 mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-p-tau181-Ab03Anti-Canine p-tau181 human monoclonal antibody (mAb)$3090.00
GMP-CAN-p-tau181-Ab04Anti-Canine p-tau181 human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-CAN-p-tau181-Ag01
Product NameCanine p-tau181
Target/BiomarkerCanine p-tau181
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Canine p-tau181 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in p-tau181 level test of animal Dog/Canine with Alzheimer Disease(AD).
TagHis
Reconized/Reactive SpecicsCanine p-tau181
Product descriptionRecombinant Canine p-tau181 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-p-tau181-Ab01,GMP-CAN-p-tau181-Ab02
Target/BiomarkerCanine p-tau181
Product NameAnti-Canine p-tau181 mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Canine p-tau181 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine p-tau181 antibodies in Canine p-tau181 level test of animal Dog/Canine with Alzheimer Disease(AD).
Product descriptionAnti-Canine p-tau181 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine p-tau181 antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-p-tau181-Ab03,GMP-CAN-p-tau181-Ab04
Target/BiomarkerCanine p-tau181
Product NameAnti-Canine p-tau181 human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Canine p-tau181 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine p-tau181 antibodies in Canine p-tau181 level test of animal Dog/Canine with Alzheimer Disease(AD).
Product descriptionAnti-Canine p-tau181 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    Canine p-tau181, the phosphorylated Tau Protein 181 variant specific to dogs, represents a molecular sentinel that resides within the intricate neural landscape of man's best friend. At its core, it is a Tau protein that has undergone a precise biochemical modification – phosphorylation – at residue 181. Tau proteins are typically associated with the stabilization of microtubules, essential components of the neuronal cytoskeleton, ensuring proper intracellular transport and structural integrity of axons.

    However, in the context of neurodegenerative diseases, the narrative takes a different turn. Phosphorylation events can lead to the misfolding and aggregation of Tau proteins. Canine p-tau181 is no exception, as it tends to aggregate and form neurofibrillary tangles (NFTs) within the neural tissues of affected dogs.

    These NFTs, akin to those observed in human neurodegenerative diseases like Alzheimer's, are a pathological hallmark of several neurodegenerative conditions in dogs. The aggregation of p-tau181 in NFTs contributes to the progressive neuronal dysfunction and cognitive decline seen in conditions such as canine cognitive dysfunction syndrome (CCDS) and specific forms of encephalopathy.



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