Canine p-tau212 and 214 antibody and antigen (recombinant protein)

Diagnostic anti-Canine p-tau212 and 214 antibodies pairs and antigen for animal health (animal Dog/Canine Alzheimer Disease(AD)) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Product information

Catalog No.	Description	US $ Price (per mg)
GMP-CAN-p-tau212-214-Ag01	Canine p-tau212 and 214	$3090.00
GMP-CAN-p-tau212-214-Ab01	Anti-Canine p-tau212 and 214 mouse monoclonal antibody (mAb)	$3090.00
GMP-CAN-p-tau212-214-Ab02	Anti-Canine p-tau212 and 214 mouse monoclonal antibody (mAb)	$3090.00
GMP-CAN-p-tau212-214-Ab03	Anti-Canine p-tau212 and 214 human monoclonal antibody (mAb)	$3090.00
GMP-CAN-p-tau212-214-Ab04	Anti-Canine p-tau212 and 214 human monoclonal antibody (mAb)	$3090.00

Size： 1mg | 10mg | 100mg

Product Description

Cat No.	GMP-CAN-p-tau212-214-Ag01
Product Name	Canine p-tau212 and 214
Target/Biomarker	Canine p-tau212 and 214
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine p-tau212 and 214 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in p-tau212 and 214 level test of animal Dog/Canine with Alzheimer Disease(AD).
Tag	His
Reconized/Reactive Specics	Canine p-tau212 and 214
Product description	Recombinant Canine p-tau212 and 214 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-CAN-p-tau212-214-Ab01,GMP-CAN-p-tau212-214-Ab02
Target/Biomarker	Canine p-tau212 and 214
Product Name	Anti-Canine p-tau212 and 214 mouse monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Recombinant Canine p-tau212 and 214 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine p-tau212 and 214 antibodies in Canine p-tau212 and 214 level test of animal Dog/Canine with Alzheimer Disease(AD).
Product description	Anti-Canine p-tau212 and 214 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine p-tau212 and 214 antibodies.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No.	GMP-CAN-p-tau212-214-Ab03,GMP-CAN-p-tau212-214-Ab04
Target/Biomarker	Canine p-tau212 and 214
Product Name	Anti-Canine p-tau212 and 214 human monoclonal antibody (mAb)
Expression platform	CHO
Isotypes	Human lgG1
Bioactivity validation	Recombinant Canine p-tau212 and 214 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine p-tau212 and 214 antibodies in Canine p-tau212 and 214 level test of animal Dog/Canine with Alzheimer Disease(AD).
Product description	Anti-Canine p-tau212 and 214 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

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Target/Biomarker Information

Canine p-tau212 and p-tau214, the phosphorylated Tau Proteins unique to dogs, occupy a pivotal role within the intricate landscape of canine neurobiology. At their core, they are Tau proteins that have undergone specific biochemical modifications – phosphorylation – at residues 212 and 214. Normally, Tau proteins in dogs play a vital role in stabilizing microtubules, essential for axonal stability and intracellular transport within neuronal cells.

However, in the context of neurodegenerative diseases, the narrative takes a different course. Phosphorylation events can trigger the misfolding and aggregation of Tau proteins, and in dogs, p-tau212 and p-tau214 tend to aggregate and form neurofibrillary tangles (NFTs) within neural tissues.

These NFTs, akin to those observed in human neurodegenerative diseases such as Alzheimer's, represent a pathological signature of various canine neurodegenerative conditions. The accumulation of p-tau212 and p-tau214 in NFTs contributes to progressive neuronal dysfunction, cognitive decline, and motor disturbances characteristic of conditions such as canine cognitive dysfunction syndrome (CCDS) and specific encephalopathies.

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