Canine p-tau212 and 214 antibody and antigen (recombinant protein)

Diagnostic anti-Canine p-tau212 and 214 antibodies pairs and antigen for animal health (animal Dog/Canine Alzheimer Disease(AD)) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Target products collectionGo to Companion Animal disease testing products collection >>


Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-CAN-p-tau212-214-Ag01Canine p-tau212 and 214$3090.00
GMP-CAN-p-tau212-214-Ab01Anti-Canine p-tau212 and 214 mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-p-tau212-214-Ab02Anti-Canine p-tau212 and 214 mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-p-tau212-214-Ab03Anti-Canine p-tau212 and 214 human monoclonal antibody (mAb)$3090.00
GMP-CAN-p-tau212-214-Ab04Anti-Canine p-tau212 and 214 human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-CAN-p-tau212-214-Ag01
Product NameCanine p-tau212 and 214
Target/BiomarkerCanine p-tau212 and 214
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Canine p-tau212 and 214 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in p-tau212 and 214 level test of animal Dog/Canine with Alzheimer Disease(AD).
TagHis
Reconized/Reactive SpecicsCanine p-tau212 and 214
Product descriptionRecombinant Canine p-tau212 and 214 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-p-tau212-214-Ab01,GMP-CAN-p-tau212-214-Ab02
Target/BiomarkerCanine p-tau212 and 214
Product NameAnti-Canine p-tau212 and 214 mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Canine p-tau212 and 214 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine p-tau212 and 214 antibodies in Canine p-tau212 and 214 level test of animal Dog/Canine with Alzheimer Disease(AD).
Product descriptionAnti-Canine p-tau212 and 214 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine p-tau212 and 214 antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-p-tau212-214-Ab03,GMP-CAN-p-tau212-214-Ab04
Target/BiomarkerCanine p-tau212 and 214
Product NameAnti-Canine p-tau212 and 214 human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Canine p-tau212 and 214 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine p-tau212 and 214 antibodies in Canine p-tau212 and 214 level test of animal Dog/Canine with Alzheimer Disease(AD).
Product descriptionAnti-Canine p-tau212 and 214 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    Canine p-tau212 and p-tau214, the phosphorylated Tau Proteins unique to dogs, occupy a pivotal role within the intricate landscape of canine neurobiology. At their core, they are Tau proteins that have undergone specific biochemical modifications – phosphorylation – at residues 212 and 214. Normally, Tau proteins in dogs play a vital role in stabilizing microtubules, essential for axonal stability and intracellular transport within neuronal cells.

    However, in the context of neurodegenerative diseases, the narrative takes a different course. Phosphorylation events can trigger the misfolding and aggregation of Tau proteins, and in dogs, p-tau212 and p-tau214 tend to aggregate and form neurofibrillary tangles (NFTs) within neural tissues.

    These NFTs, akin to those observed in human neurodegenerative diseases such as Alzheimer's, represent a pathological signature of various canine neurodegenerative conditions. The accumulation of p-tau212 and p-tau214 in NFTs contributes to progressive neuronal dysfunction, cognitive decline, and motor disturbances characteristic of conditions such as canine cognitive dysfunction syndrome (CCDS) and specific encephalopathies.



    About GDU


    GDU

    GDU helps global diagnostic partners in high quality of raw material discovery, development, and application. GDU believes in Protein&antibody Innovation for more reliable diagnostic solutions.