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Canine p-tau217 antibody and antigen (recombinant protein)
Diagnostic anti-Canine p-tau217 antibodies pairs and antigen for animal health (animal Dog/Canine Alzheimer Disease(AD)) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT
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Product information
| Catalog No. | Description | US $ Price (per mg) |
|---|---|---|
| GMP-CAN-p-tau217-Ag01 | Canine p-tau217 | $3090.00 |
| GMP-CAN-p-tau217-Ab01 | Anti-Canine p-tau217 mouse monoclonal antibody (mAb) | $3090.00 |
| GMP-CAN-p-tau217-Ab02 | Anti-Canine p-tau217 mouse monoclonal antibody (mAb) | $3090.00 |
| GMP-CAN-p-tau217-Ab03 | Anti-Canine p-tau217 human monoclonal antibody (mAb) | $3090.00 |
| GMP-CAN-p-tau217-Ab04 | Anti-Canine p-tau217 human monoclonal antibody (mAb) | $3090.00 |
Size： 1mg | 10mg | 100mg
Product Description
| Cat No. | GMP-CAN-p-tau217-Ag01 |
| Product Name | Canine p-tau217 |
| Target/Biomarker | Canine p-tau217 |
| Expression platform | E.coli |
| Isotypes | Recombinant Antigen |
| Bioactivity validation | Anti-Canine p-tau217 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in p-tau217 level test of animal Dog/Canine with Alzheimer Disease(AD). |
| Tag | His | Reconized/Reactive Specics | Canine p-tau217 |
| Product description | Recombinant Canine p-tau217 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus. |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
| Cat No. | GMP-CAN-p-tau217-Ab01,GMP-CAN-p-tau217-Ab02 |
| Target/Biomarker | Canine p-tau217 |
| Product Name | Anti-Canine p-tau217 mouse monoclonal antibody (mAb) |
| Expression platform | CHO |
| Isotypes | Mouse IgG |
| Bioactivity validation | Recombinant Canine p-tau217 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine p-tau217 antibodies in Canine p-tau217 level test of animal Dog/Canine with Alzheimer Disease(AD). |
| Product description | Anti-Canine p-tau217 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine p-tau217 antibodies. |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
| Cat No. | GMP-CAN-p-tau217-Ab03,GMP-CAN-p-tau217-Ab04 |
| Target/Biomarker | Canine p-tau217 |
| Product Name | Anti-Canine p-tau217 human monoclonal antibody (mAb) |
| Expression platform | CHO |
| Isotypes | Human lgG1 |
| Bioactivity validation | Recombinant Canine p-tau217 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine p-tau217 antibodies in Canine p-tau217 level test of animal Dog/Canine with Alzheimer Disease(AD). |
| Product description | Anti-Canine p-tau217 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair. |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Validation Data
Click to get more Data / Case study about the product.
Target/Biomarker Information
Canine p-tau217, the phosphorylated Tau Protein 217 variant specific to dogs, represents a molecular sentinel that resides within the complex neural landscape of our canine companions. At its core, it is a Tau protein that has undergone a precise biochemical modification – phosphorylation – specifically at residue 217. Tau proteins are typically involved in the stabilization of microtubules within neuronal cells, ensuring proper intracellular transport and the structural integrity of axons.
However, in the context of neurodegenerative diseases, the narrative takes a different turn. Phosphorylation events can lead to the misfolding and aggregation of Tau proteins, and canine p-tau217 is no exception. It tends to aggregate and form neurofibrillary tangles (NFTs) within the neural tissues of affected dogs.
These NFTs, reminiscent of those observed in human neurodegenerative diseases like Alzheimer's, are a pathological hallmark of various neurodegenerative conditions in dogs. The aggregation of p-tau217 in NFTs contributes to progressive neuronal dysfunction, cognitive decline, and motor disturbances, as seen in conditions such as canine Alzheimer's disease and specific encephalopathies.
About GDU
GDU helps global diagnostic partners in high quality of raw material discovery, development, and application. GDU believes in Protein&antibody Innovation for more reliable diagnostic solutions.
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