Canine p-tau231 antibody and antigen (recombinant protein)

Diagnostic anti-Canine p-tau231 antibodies pairs and antigen for animal health (animal Dog/Canine Alzheimer Disease(AD)) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Target products collectionGo to Companion Animal disease testing products collection >>


Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-CAN-p-tau231-Ag01Canine p-tau231$3090.00
GMP-CAN-p-tau231-Ab01Anti-Canine p-tau231 mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-p-tau231-Ab02Anti-Canine p-tau231 mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-p-tau231-Ab03Anti-Canine p-tau231 human monoclonal antibody (mAb)$3090.00
GMP-CAN-p-tau231-Ab04Anti-Canine p-tau231 human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-CAN-p-tau231-Ag01
Product NameCanine p-tau231
Target/BiomarkerCanine p-tau231
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Canine p-tau231 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in p-tau231 level test of animal Dog/Canine with Alzheimer Disease(AD).
TagHis
Reconized/Reactive SpecicsCanine p-tau231
Product descriptionRecombinant Canine p-tau231 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-p-tau231-Ab01,GMP-CAN-p-tau231-Ab02
Target/BiomarkerCanine p-tau231
Product NameAnti-Canine p-tau231 mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Canine p-tau231 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine p-tau231 antibodies in Canine p-tau231 level test of animal Dog/Canine with Alzheimer Disease(AD).
Product descriptionAnti-Canine p-tau231 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine p-tau231 antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-p-tau231-Ab03,GMP-CAN-p-tau231-Ab04
Target/BiomarkerCanine p-tau231
Product NameAnti-Canine p-tau231 human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Canine p-tau231 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine p-tau231 antibodies in Canine p-tau231 level test of animal Dog/Canine with Alzheimer Disease(AD).
Product descriptionAnti-Canine p-tau231 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    Canine p-tau231, the phosphorylated Tau Protein 231 variant specific to dogs, represents a molecular sentinel within the intricate landscape of canine neurobiology. At its core, it is a Tau protein that has undergone a precise biochemical modification – phosphorylation – specifically at residue 231. Tau proteins normally play a crucial role in stabilizing microtubules within neuronal cells, ensuring proper intracellular transport and the structural integrity of axons.

    However, in the context of neurodegenerative diseases, the narrative takes a different turn. Phosphorylation events can lead to the misfolding and aggregation of Tau proteins, and canine p-tau231 is no exception. It tends to aggregate and form neurofibrillary tangles (NFTs) within the neural tissues of affected dogs.

    These NFTs, reminiscent of those observed in human neurodegenerative diseases like Alzheimer's, are a pathological hallmark of various neurodegenerative conditions in dogs. The aggregation of p-tau231 in NFTs contributes to progressive neuronal dysfunction, cognitive decline, and motor disturbances, as seen in conditions such as canine Alzheimer's disease and specific encephalopathies.



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