Canine p-tau422 antibody and antigen (recombinant protein)

Diagnostic anti-Canine p-tau422 antibodies pairs and antigen for animal health (animal Dog/Canine Alzheimer Disease(AD)) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Target products collectionGo to Companion Animal disease testing products collection >>


Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-CAN-p-tau422-Ag01Canine p-tau422$3090.00
GMP-CAN-p-tau422-Ab01Anti-Canine p-tau422 mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-p-tau422-Ab02Anti-Canine p-tau422 mouse monoclonal antibody (mAb)$3090.00
GMP-CAN-p-tau422-Ab03Anti-Canine p-tau422 human monoclonal antibody (mAb)$3090.00
GMP-CAN-p-tau422-Ab04Anti-Canine p-tau422 human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-CAN-p-tau422-Ag01
Product NameCanine p-tau422
Target/BiomarkerCanine p-tau422
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Canine p-tau422 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in p-tau422 level test of animal Dog/Canine with Alzheimer Disease(AD).
TagHis
Reconized/Reactive SpecicsCanine p-tau422
Product descriptionRecombinant Canine p-tau422 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-p-tau422-Ab01,GMP-CAN-p-tau422-Ab02
Target/BiomarkerCanine p-tau422
Product NameAnti-Canine p-tau422 mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Canine p-tau422 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine p-tau422 antibodies in Canine p-tau422 level test of animal Dog/Canine with Alzheimer Disease(AD).
Product descriptionAnti-Canine p-tau422 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine p-tau422 antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-CAN-p-tau422-Ab03,GMP-CAN-p-tau422-Ab04
Target/BiomarkerCanine p-tau422
Product NameAnti-Canine p-tau422 human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Canine p-tau422 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Canine p-tau422 antibodies in Canine p-tau422 level test of animal Dog/Canine with Alzheimer Disease(AD).
Product descriptionAnti-Canine p-tau422 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    Canine p-tau422 stands as a pivotal biomarker, intricately intertwined with the neurology of dogs. This phosphorylated tau variant is predominantly localized within the central nervous system (CNS) of canines, where it fulfills a fundamental role in the maintenance of neuronal microtubules' structural integrity.

    Structurally, Canine p-tau422 belongs to the tau protein family, sharing genetic and functional homology with its human counterpart. Under normal circumstances, tau proteins like p-tau422 bind to microtubules and assist in their assembly. This function is vital for proper axonal transport, synaptic plasticity, and overall neuronal function.

    However, in the context of neurodegenerative conditions observed in dogs, tau proteins like p-tau422 undergo abnormal phosphorylation. This post-translational modification results in tau proteins adopting atypical conformations, rendering them susceptible to aggregation. The aggregation of tau proteins culminates in the formation of neurofibrillary tangles within neurons, a hallmark of neurodegenerative diseases analogous to Alzheimer's disease in humans.

    The presence of elevated levels of p-tau422 is indicative of these pathological processes and serves as an early warning signal of potential cognitive and neurological deficits in affected dogs.



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