Equine p-tau181 antibody and antigen (recombinant protein)

Diagnostic anti-Equine p-tau181 antibodies pairs and antigen for animal health (animal Equine/Horse Alzheimer Disease(AD)) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Target products collectionGo to Equine disease testing products collection >>


Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-EQU-p-tau181-Ag01Equine p-tau181$3090.00
GMP-EQU-p-tau181-Ab01Anti-Equine p-tau181 mouse monoclonal antibody (mAb)$3090.00
GMP-EQU-p-tau181-Ab02Anti-Equine p-tau181 mouse monoclonal antibody (mAb)$3090.00
GMP-EQU-p-tau181-Ab03Anti-Equine p-tau181 human monoclonal antibody (mAb)$3090.00
GMP-EQU-p-tau181-Ab04Anti-Equine p-tau181 human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-EQU-p-tau181-Ag01
Product NameEquine p-tau181
Target/BiomarkerEquine p-tau181
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Equine p-tau181 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in p-tau181 level test of animal Equine/Horse with Alzheimer Disease(AD).
TagHis
Reconized/Reactive SpecicsEquine p-tau181
Product descriptionRecombinant Equine p-tau181 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-EQU-p-tau181-Ab01,GMP-EQU-p-tau181-Ab02
Target/BiomarkerEquine p-tau181
Product NameAnti-Equine p-tau181 mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Equine p-tau181 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Equine p-tau181 antibodies in Equine p-tau181 level test of animal Equine/Horse with Alzheimer Disease(AD).
Product descriptionAnti-Equine p-tau181 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Equine p-tau181 antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-EQU-p-tau181-Ab03,GMP-EQU-p-tau181-Ab04
Target/BiomarkerEquine p-tau181
Product NameAnti-Equine p-tau181 human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Equine p-tau181 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Equine p-tau181 antibodies in Equine p-tau181 level test of animal Equine/Horse with Alzheimer Disease(AD).
Product descriptionAnti-Equine p-tau181 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    Equine p-tau181, the phosphorylated Tau Protein 181 variant specific to horses, is a beacon within the intricate landscape of equine neurobiology. At its core, it is a Tau protein that has undergone precise phosphorylation at residue 181. Under normal circumstances, Tau proteins serve as the guardians of microtubule stability within neuronal cells, ensuring proper intracellular transport and the structural integrity of axons.

    However, when neurodegenerative processes take center stage, the narrative evolves. Phosphorylation events can trigger the misfolding and aggregation of Tau proteins, and equine p-tau181 is no exception. It tends to aggregate and form neurofibrillary tangles within the neural tissues of afflicted horses.

    These neurofibrillary tangles, reminiscent of those observed in human neurodegenerative diseases such as Alzheimer's, are a pathological hallmark of various equine neurodegenerative conditions. The accumulation of p-tau181 in neurofibrillary tangles contributes to progressive neuronal dysfunction, ultimately manifesting as clinical signs in conditions like equine neuroaxonal dystrophy (eNAD) and specific encephalopathies.



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    GDU

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