Feline p-tau212 and 214 antibody and antigen (recombinant protein)

Diagnostic anti-Feline p-tau212 and 214 antibodies pairs and antigen for animal health (animal Cat/Feline Alzheimer Disease(AD)) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Target products collectionGo to Companion Animal disease testing products collection >>


Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-FEL-p-tau212-214-Ag01Feline p-tau212 and 214$3090.00
GMP-FEL-p-tau212-214-Ab01Anti-Feline p-tau212 and 214 mouse monoclonal antibody (mAb)$3090.00
GMP-FEL-p-tau212-214-Ab02Anti-Feline p-tau212 and 214 mouse monoclonal antibody (mAb)$3090.00
GMP-FEL-p-tau212-214-Ab03Anti-Feline p-tau212 and 214 human monoclonal antibody (mAb)$3090.00
GMP-FEL-p-tau212-214-Ab04Anti-Feline p-tau212 and 214 human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-FEL-p-tau212-214-Ag01
Product NameFeline p-tau212 and 214
Target/BiomarkerFeline p-tau212 and 214
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Feline p-tau212 and 214 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in p-tau212 and 214 level test of animal Cat/Feline with Alzheimer Disease(AD).
TagHis
Reconized/Reactive SpecicsFeline p-tau212 and 214
Product descriptionRecombinant Feline p-tau212 and 214 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-FEL-p-tau212-214-Ab01,GMP-FEL-p-tau212-214-Ab02
Target/BiomarkerFeline p-tau212 and 214
Product NameAnti-Feline p-tau212 and 214 mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Feline p-tau212 and 214 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline p-tau212 and 214 antibodies in Feline p-tau212 and 214 level test of animal Cat/Feline with Alzheimer Disease(AD).
Product descriptionAnti-Feline p-tau212 and 214 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline p-tau212 and 214 antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-FEL-p-tau212-214-Ab03,GMP-FEL-p-tau212-214-Ab04
Target/BiomarkerFeline p-tau212 and 214
Product NameAnti-Feline p-tau212 and 214 human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Feline p-tau212 and 214 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline p-tau212 and 214 antibodies in Feline p-tau212 and 214 level test of animal Cat/Feline with Alzheimer Disease(AD).
Product descriptionAnti-Feline p-tau212 and 214 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    Feline p-tau212 and p-tau214, constituents of the tau protein family, represent a captivating facet of feline neurobiology. These phosphorylated tau variants are specifically tailored to the intricate neural landscape of cats, playing a pivotal role in maintaining neuronal stability and axonal integrity. However, the story of p-tau212 and p-tau214 takes a dramatic turn in the context of neurodegenerative diseases in felines.

    At its core, tau is a microtubule-associated protein that binds to and stabilizes microtubules within neurons. This function is vital for maintaining the structural integrity of neurons and facilitating essential processes such as axonal transport. Tau phosphorylation, a naturally occurring process, regulates its interaction with microtubules. However, when tau becomes hyperphosphorylated, as observed in neurodegenerative conditions, it undergoes a transformation that renders it dysfunctional.

    Feline p-tau212 and p-tau214 are two specific sites of phosphorylation on the tau protein that hold a particular clinical significance in cats. These phosphorylated forms are notorious for their propensity to form aggregates and insoluble structures, known as neurofibrillary tangles. These tangles wreak havoc within feline neurons, disrupting axonal transport, and impairing neuronal function. The consequence is the gradual but relentless cognitive decline observed in aging cats and those affected by conditions like feline cognitive dysfunction syndrome (FCDS).



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