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The world is in midst of the COVID-19 pandemic. Previously known as B.1.617.2, the variant was first discovered in India in February, where it contributed to a horrific wave of infections which started in the spring: The Economist estimates that there have been more than 1m covid deaths in India this year. The delta variant has spread rapidly across borders, too. According to GISAID, the mutation has been identified in at least 70 countries. The delta variant is the most dangerous SARS-CoV-2 mutation yet.1

Mutations of Spike protein in SARS-COV-2 (2019nCOV) delta variant B.1.617.2 lineage


Two of the spike mutations are at key residues in the RBD (L452R and T478K), two are in the N-terminal domain (T19R and FR157-158Δ).2.

Spike Mutation
in SARS-COV-2
(2019nCOV)
delta variant
B.1.617.2 lineage
Spike-S1 Subunit
N Terminal
T19R
FR157-158Δ
Spike-RBD L452R Important residues
mutation
T478K Important residues
mutation
Spike-S1 Subunit D614G A popular mutation in
different new SARS-CoV-2
lineage
Spike-S2 Subunit P681R
D950N

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Figure. Amino acid changes in the spike region of the 190 S501Y.V2 genomes2,3

GeneMedi pseudotype virus (pseudovirus) of SARS-COV-2 (2019nCOV) delta variant B.1.617.2 lineage

SARS-COV-2 (2019nCOV) -delta variant B.1.617.2 lineage of Spike protein & ACE2 competition binding assay for efficacy evaluation of COVID-19 vaccines and therapeutic antibodies

GeneMedi codon-optimized spike mammalian expression vector for SARS-COV-2 (2019nCOV) -delta variant B.1.617.2 lineage

GeneMedi designed a mammalian expression codon-optimized spike mutation/deletion variant vector for COVID-19 SARS-COV-2 (2019nCOV) delta variant B.1.617.2 lineage.

Cat No. Gene &Vector description of 2019 nCoV Vector Tag Coden Optimized Order
GMV-V-2019nCoV-153 pGM-2019nCoV-Spike(S1+S2)- L452R mutation pcDNA3.1(+) No tag coden optimized for mamamlian Picture loading failed.
GMV-V-2019nCoV-154 Ad-2019nCoV-Spike(S1+S2)- L452R mutation Pre-made adenovirus C-3FLAG coden optimized for mamamlian Picture loading failed.
GMV-V-2019nCoV-155 pGMLV-2019nCoV-Spike(S1+S2)-L452R mutation Lentiviral vector C-3FLAG coden optimized for mamamlian Picture loading failed.
GMV-V-2019nCoV-171 pGM-2019nCoV-Spike(S1+S2)-T478K mutation (delta variant B.1.617.2 lineage) pcDNA3.1(+) No tag coden optimized for mamamlian Picture loading failed.
GMV-V-2019nCoV-172 Ad-2019nCoV-Spike(S1+S2)-T478K mutation (delta variant B.1.617.2 lineage) Pre-made adenovirus C-3FLAG coden optimized for mamamlian Picture loading failed.
GMV-V-2019nCoV-173 pGMLV-2019nCoV-Spike(S1+S2)-T478K mutation(delta variant B.1.617.2 lineage) Lentiviral vector C-3FLAG coden optimized for mamamlian Picture loading failed.
GMV-V-2019nCoV-174 pGM-Spike(S1+S2)RBD mutation (L452R+T478K) of delta variant B.1.617.2 lineage pcDNA3.1(+) No tag coden optimized for mamamlian Picture loading failed.
GMV-V-2019nCoV-175 Ad-Spike(S1+S2)RBD mutation (L452R+T478K) of delta variant B.1.617.2 lineage Pre-made adenovirus C-3FLAG coden optimized for mamamlian Picture loading failed.
GMV-V-2019nCoV-176 pGMLV-Spike(S1+S2)RBD mutation (L452R+T478K) of delta variant B.1.617.2 lineage Lentiviral vector C-3FLAG coden optimized for mamamlian Picture loading failed.
GMV-V-2019nCoV-054 pGM-2019nCoV-Spike(S1+S2)- D614G mutation pcDNA3.1(+) No tag coden optimized for mamamlian Picture loading failed.
GMV-V-2019nCoV-056 Ad-2019nCoV-Spike(S1+S2)- D614G mutation Pre-made adenovirus C-3FLAG coden optimized for mamamlian Picture loading failed.
GMV-V-2019nCoV-117 pGMLV-2019nCoV-Spike(S1+S2)-D614G mutation Lentiviral vector C-3FLAG coden optimized for mamamlian Picture loading failed.
GMV-V-2019nCoV-177 pGM-Spike (S1+S2) whole mutation variant of SARS-CoV-2(2019nCoV) delta variant B.1.617.2 lineage pcDNA3.1(+) No tag coden optimized for mamamlian Picture loading failed.
GMV-V-2019nCoV-178 Ad-Spike (S1+S2) whole mutation variant of SARS-CoV-2(2019nCoV) delta variant B.1.617.2 lineage Pre-made adenovirus C-3FLAG coden optimized for mamamlian Picture loading failed.
GMV-V-2019nCoV-179 pGMLV-Spike (S1+S2) whole mutation variant of SARS-CoV-2(2019nCoV) delta variant B.1.617.2 lineag Lentiviral vector C-3FLAG coden optimized for mamamlian Picture loading failed.

Reference

1.The delta variant is the most dangerous SARS-CoV-2 mutation yet. https://www.economist.com/graphic-detail/2021/06/16/-delta-variant-is-the-most-dangerous-sars-cov-2-mutation-yet.

2.B.1.617.2 lineage Report. https://outbreak.info/situation-reports?pango=B.1.617.2.

3.Spike Variants. https://covdb.stanford.edu/page/mutation-viewer/#sec_delta.



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