Human CYP3A4/CP33/ CP34 ORF/cDNA clone-Adenovirus plasmid (BC069418)

Product information

Catalog No.	Product Name	Plasmid Grade	Plasmid quantity
pGMAP000372	Human CYP3A4 Adenovirus plasmid	Research Grade	10mg, 50mg, 100mg, 500mg, >1g
		GMP-like Grade	10mg, 50mg, 100mg, 500mg, >1g
		High Quality (HQ) Grade
		Seed	5ug

Product Description

Catalog ID	pGMAP000372
Gene Name	CYP3A4
Accession Number	BC069418
Gene ID	1576
Species	Human
Product Type	Adenovirus plasmid (overexpression)
Insert Length	1512 bp
Gene Alias	CP33, CP34, CYP3A, HLP, NF-25, P450C3, P450PCN1
Fluorescent Reporter	ZsGreen
Mammalian Cell Selection	Puromyocin
Fusion Tag	3xflag (C-Terminal)
Promoter	CMV
Resistance	Amplicin
Sequence	ATGGCTCTCATCCCAGACTTGGCCATGGAAACCTGGCTTCTCCTGGCTGTCAGCCTGGTGCTCCTCTATCTATATGGAACCCATTCACATGGACTTTTTAAGAAGCTTGGAATTCCAGGGCCCACACCTCTGCCTTTTTTGGGAAATATTTTGTCCTACCATAAGGGCTTTTGTATGTTTGACATGGAATGTCATAAAAAGTATGGAAAAGTGTGGGGCTTTTATGATGGTCAACAGCCTGTGCTGGCTATCACAGATCCTGACATGATCAAAACAGTGCTAGTGAAAGAATGTTATTCTGTCTTCACAAACCGGAGGCCTTTTGGTCCAGTGGGATTTATGAAAAGTGCCATCTCTATAGCTGAGGATGAAGAATGGAAGAGATTACGATCATTGCTGTCTCCAACCTTCACCAGTGGAAAACTCAAGGAGATGGTCCCTATCATTGCCCAGTATGGAGATGTGTTGGTGAGAAATCTGAGGCGGGAAGCAGAGACAGGCAAGCCTGTCACCTTGAAAGACGTCTTTGGGGCCTACAGCATGGATGTGATCACTAGCACATCATTTGGAGTGAACATCGACTCTCTCAACAATCCACAAGACCCCTTTGTGGAAAACACCAAGAAGCTTTTAAGATTTGATTTTTTGGATCCATTCTTTCTCTCAATAACAGTCTTTCCATTCCTCATCCCAATTCTTGAAGTATTAAATATCTGTGTGTTTCCAAGAGAAGTTACAAATTTTTTAAGAAAATCTGTAAAAAGGATGAAAGAAAGTCGCCTCGAAGATACACAAAAGCACCGAGTGGATTTCCTTCAGCTGATGATTGACTCTCAGAATTCAAAAGAAACTGAGTCCCACAAAGCTCTGTCCGATCTGGAGCTCGTGGCCCAATCAATTATCTTTATTTTTGCTGGCTATGAAACCACGAGCAGTGTTCTCTCCTTCATTATGTATGAACTGGCCACTCACCCTGATGTCCAGCAGAAACTGCAGGAGGAAATTGATGCAGTTTTACCCAATAAGGCACCACCCACCTATGATACTGTGCTACAGATGGAGTATCTTGACATGGTGGTGAATGAAACGCTCAGATTATTCCCAATTGCTATGAGACTTGAGAGGGTCTGCAAAAAAGATGTTGAGATCAATGGGATGTTCATTCCCAAAGGGGTGGTGGTGATGATTCCAAGCTATGCTCTTCACCGTGACCCAAAGTACTGGACAGAGCCTGAGAAGTTCCTCCCTGAAAGATTCAGCAAGAAGAACAAGGACAACATAGATCCTTACATATACACACCCTTTGGAAGTGGACCCAGAAACTGCATTGGCATGAGGTTTGCTCTCATGAACATGAAACTTGCTCTAATCAGAGTCCTTCAGAACTTCTCCTTCAAACCTTGTAAAGAAACACAGATCCCCCTGAAATTAAGCTTAGGAGGACTTCTTCAACCAGAAAAACCCGTTGTTCTAAAGGTTGAGTCAAGGGATGGCACCGTAAGTGGAGCCTGA

Reference

Data / case study

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Associated products

Category	Cat No.	Products Name
Target Antibody	GM-Tg-g-IP0038-Ab	Anti-CYP3A4 monoclonal antibody
Target Antigen	GM-Tg-g-IP0038-Ag	CYP3A4 protein
ORF Viral Vector	pGMAP000372	Human CYP3A4 Adenovirus plasmid
ORF Viral Vector	vGMAP000372	Human CYP3A4 Adenovirus particle
ORF Viral Vector	pGMLV002275	Human CYP3A4 Lentivirus plasmid

Target information

Target ID	GM-IP0038
Target Name	CYP3A4
Gene ID	1576
Gene Symbol and Synonyms	CP33,CP34,CYP3A,CYP3A3,CYP3A4,CYPIIIA3,CYPIIIA4,HLP,NF-25,P450C3,P450PCN1,VDDR3
Uniprot Accession	P08684
Uniprot Entry Name	CP3A4_HUMAN
Protein Sub-location	Introcelluar Protein
Category	Therapeutics Target
Disease	Cancer
Gene Ensembl	ENSG00000160868
Target Classification	Tumor-associated antigen (TAA)

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam, erythromycin, and chloroquine. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2020]

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