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Anti-PRKAA2 monoclonal antibody
Pre-made anti-PRKAA2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to PRKAA2/PRKAA2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1444-Ab-1/ GM-Tg-hg-IP1444-Ab-2 | Anti-Human PRKAA2 monoclonal antibody | Human |
| GM-Tg-rg-IP1444-Ab-1/ GM-Tg-rg-IP1444-Ab-2 | Anti-Rat PRKAA2 monoclonal antibody | Rat |
| GM-Tg-mg-IP1444-Ab-1/ GM-Tg-mg-IP1444-Ab-2 | Anti-Mouse PRKAA2 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1444-Ab-1/ GM-Tg-cynog-IP1444-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PRKAA2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1444-Ab-1/ GM-Tg-felg-IP1444-Ab-2 | Anti-Feline PRKAA2 monoclonal antibody | Feline |
| GM-Tg-cang-IP1444-Ab-1/ GM-Tg-cang-IP1444-Ab-2 | Anti-Canine PRKAA2 monoclonal antibody | Canine |
| GM-Tg-bovg-IP1444-Ab-1/ GM-Tg-bovg-IP1444-Ab-2 | Anti-Bovine PRKAA2 monoclonal antibody | Bovine |
| GM-Tg-equg-IP1444-Ab-1/ GM-Tg-equg-IP1444-Ab-2 | Anti-Equine PRKAA2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1444-Ab-1/ GM-Tg-hg-IP1444-Ab-2; GM-Tg-rg-IP1444-Ab-1/ GM-Tg-rg-IP1444-Ab-2; GM-Tg-mg-IP1444-Ab-1/ GM-Tg-mg-IP1444-Ab-2; GM-Tg-cynog-IP1444-Ab-1/ GM-Tg-cynog-IP1444-Ab-2; GM-Tg-felg-IP1444-Ab-1/ GM-Tg-felg-IP1444-Ab-2; GM-Tg-cang-IP1444-Ab-1/ GM-Tg-cang-IP1444-Ab-2; GM-Tg-bovg-IP1444-Ab-1/ GM-Tg-bovg-IP1444-Ab-2; GM-Tg-equg-IP1444-Ab-1/ GM-Tg-equg-IP1444-Ab-2 |
| Products Name | Anti-PRKAA2 monoclonal antibody |
| Format | mab |
| Target Name | PRKAA2 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-PRKAA2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1444-Ag-1 | Recombinant multi-species AAPK2/ PRKAA2/ AMPK protein |
| ORF Viral Vector | pGMLP001356 | human PRKAA2 Lentivirus plasmid |
| ORF Viral Vector | pGMLP001898 | human PRKAA2 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001356 | human PRKAA2 Lentivirus particle |
| ORF Viral Vector | vGMLP001898 | human PRKAA2 Lentivirus particle |
| ORF Viral Vector | pGMAAV000081 | rat Prkaa2 AAV plasmid |
| ORF Viral Vector | pGMLPm004043 | mouse Prkaa2 Lentivirus plasmid |
| ORF Viral Vector | vGMAAV000081 | rat Prkaa2 AAV particle |
| ORF Viral Vector | vGMLPm004043 | mouse Prkaa2 Lentivirus particle |
Target information
| Target ID | GM-IP1444 |
| Target Name | PRKAA2 |
| Gene ID | 5563,108079,78975,717703,489571,101096000,538954,100034159 |
| Gene Symbol and Synonyms | 2310008I11Rik,A830082D05,AMPK,AMPK2,AMPKa2,AMPKalpha2,PRKAA,PRKAA2 |
| Uniprot Accession | P54646,Q09137 |
| Uniprot Entry Name | AAPK2_HUMAN,AAPK2_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000162409 |
| Target Classification | Kinase |
The target: PRKAA2, gene name: PRKAA2, also named as AMPK, AMPK2, AMPKa2, PRKAA. The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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