Anti-CLD7/ CLDN7/ CEPTRL2 monoclonal antibody

Anti-CLD7/ CLDN7/ CEPTRL2 antibody for FACS & in-vivo assay

Target products collectionGo to CLDN7/CLDN7 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0286-Ab-1/ GM-Tg-hg-MP0286-Ab-2Anti-Human CLDN7 monoclonal antibodyHuman
GM-Tg-rg-MP0286-Ab-1/ GM-Tg-rg-MP0286-Ab-2Anti-Rat CLDN7 monoclonal antibodyRat
GM-Tg-mg-MP0286-Ab-1/ GM-Tg-mg-MP0286-Ab-2Anti-Mouse CLDN7 monoclonal antibodyMouse
GM-Tg-cynog-MP0286-Ab-1/ GM-Tg-cynog-MP0286-Ab-2Anti-Cynomolgus/ Rhesus macaque CLDN7 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0286-Ab-1/ GM-Tg-felg-MP0286-Ab-2Anti-Feline CLDN7 monoclonal antibodyFeline
GM-Tg-cang-MP0286-Ab-1/ GM-Tg-cang-MP0286-Ab-2Anti-Canine CLDN7 monoclonal antibodyCanine
GM-Tg-bovg-MP0286-Ab-1/ GM-Tg-bovg-MP0286-Ab-2Anti-Bovine CLDN7 monoclonal antibodyBovine
GM-Tg-equg-MP0286-Ab-1/ GM-Tg-equg-MP0286-Ab-2Anti-Equine CLDN7 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0286-Ab-1/ GM-Tg-hg-MP0286-Ab-2; GM-Tg-rg-MP0286-Ab-1/ GM-Tg-rg-MP0286-Ab-2;
GM-Tg-mg-MP0286-Ab-1/ GM-Tg-mg-MP0286-Ab-2; GM-Tg-cynog-MP0286-Ab-1/ GM-Tg-cynog-MP0286-Ab-2;
GM-Tg-felg-MP0286-Ab-1/ GM-Tg-felg-MP0286-Ab-2; GM-Tg-cang-MP0286-Ab-1/ GM-Tg-cang-MP0286-Ab-2;
GM-Tg-bovg-MP0286-Ab-1/ GM-Tg-bovg-MP0286-Ab-2; GM-Tg-equg-MP0286-Ab-1/ GM-Tg-equg-MP0286-Ab-2
Products NameAnti-CLDN7 monoclonal antibody
Formatmab
Target NameCLDN7
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CLDN7 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CLD7/ CLDN7/ CEPTRL2 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLP000382human CLDN7 Lentivirus plasmid
    ORF Viral VectorvGMAP000040Human CLDN7 Adenovirus particle
    ORF Viral VectorvGMLP000382human CLDN7 Lentivirus particle
    ORF Viral VectorpGMAP000104Human CLDN7 Adenovirus plasmid
    ORF Viral VectorvGMAP000104Human CLDN7 Adenovirus particle
    ORF Viral VectorpGMAP000040Human CLDN7 Adenovirus plasmid
    ORF Viral VectorpGMLPm000354mouse Cldn7 Lentivirus plasmid
    ORF Viral VectorvGMLPm000354mouse Cldn7 Lentivirus particle


    Target information

    Target IDGM-MP0286
    Target NameCLDN7
    Gene ID1366,53624,65132,714647,489466,101096019,512975,100072960
    Gene Symbol and SynonymsCEPTRL2,claudin-1,cld-7,CLDN-7,CLDN7,CPETRL2,Hs.84359
    Uniprot AccessionO95471,Q9Z1L1,Q3B7N4
    Uniprot Entry NameCLD7_HUMAN,CLD7_RAT,CLD7_BOVIN
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseCancer
    Gene EnsemblENSG00000181885
    Target ClassificationTumor-associated antigen (TAA)

    The target: CLDN7, gene name: CLDN7, also named as CEPTRL2, CLDN-7, CPETRL2, Hs.84359, claudin-1. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.