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Anti-TLC3A/ FAM57A/ CT120 monoclonal antibody
Anti-TLC3A/ FAM57A/ CT120 antibody for FACS & in-vivo assay
Go to FAM57A/FAM57A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP0433-Ab-1/ GM-Tg-hg-MP0433-Ab-2 | Anti-Human FAM57A monoclonal antibody | Human |
| GM-Tg-rg-MP0433-Ab-1/ GM-Tg-rg-MP0433-Ab-2 | Anti-Rat FAM57A monoclonal antibody | Rat |
| GM-Tg-mg-MP0433-Ab-1/ GM-Tg-mg-MP0433-Ab-2 | Anti-Mouse FAM57A monoclonal antibody | Mouse |
| GM-Tg-cynog-MP0433-Ab-1/ GM-Tg-cynog-MP0433-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FAM57A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP0433-Ab-1/ GM-Tg-felg-MP0433-Ab-2 | Anti-Feline FAM57A monoclonal antibody | Feline |
| GM-Tg-cang-MP0433-Ab-1/ GM-Tg-cang-MP0433-Ab-2 | Anti-Canine FAM57A monoclonal antibody | Canine |
| GM-Tg-bovg-MP0433-Ab-1/ GM-Tg-bovg-MP0433-Ab-2 | Anti-Bovine FAM57A monoclonal antibody | Bovine |
| GM-Tg-equg-MP0433-Ab-1/ GM-Tg-equg-MP0433-Ab-2 | Anti-Equine FAM57A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP0433-Ab-1/ GM-Tg-hg-MP0433-Ab-2; GM-Tg-rg-MP0433-Ab-1/ GM-Tg-rg-MP0433-Ab-2; GM-Tg-mg-MP0433-Ab-1/ GM-Tg-mg-MP0433-Ab-2; GM-Tg-cynog-MP0433-Ab-1/ GM-Tg-cynog-MP0433-Ab-2; GM-Tg-felg-MP0433-Ab-1/ GM-Tg-felg-MP0433-Ab-2; GM-Tg-cang-MP0433-Ab-1/ GM-Tg-cang-MP0433-Ab-2; GM-Tg-bovg-MP0433-Ab-1/ GM-Tg-bovg-MP0433-Ab-2; GM-Tg-equg-MP0433-Ab-1/ GM-Tg-equg-MP0433-Ab-2 |
| Products Name | Anti-FAM57A monoclonal antibody |
| Format | mab |
| Target Name | FAM57A |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-FAM57A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species TLC3A/ FAM57A/ CT120 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP003275 | human FAM57A Lentivirus particle |
| ORF Viral Vector | pGMLP003275 | human FAM57A Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001924 | mouse Fam57a Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001924 | mouse Fam57a Lentivirus particle |
Target information
| Target ID | GM-MP0433 |
| Target Name | FAM57A |
| Gene ID | 79850,116972,100360533,699707,480642,101088125,508425,100072283 |
| Gene Symbol and Synonyms | 2310047D13Rik,4932415L08Rik,5430402E13Rik,5430420K21Rik,CT120,FAM57A,RGD1307493,TLCD3A,Wdt3 |
| Uniprot Accession | Q8TBR7 |
| Uniprot Entry Name | TLC3A_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000167695 |
| Target Classification | N/A |
The target: FAM57A, gene name: FAM57A, also named as CT120. The protein encoded by this gene is a membrane-associated protein that promotes lung carcinogenesis. The encoded protein may be involved in amino acid transport and glutathione metabolism since it can interact with a solute carrier family member (SLC3A2) and an isoform of gamma-glutamyltranspeptidase-like 3. An alternatively spliced variant encoding a protein that lacks a 32 aa internal segment showed the opposite effect, inhibiting lung cancer cell growth. Knockdown of this gene also inhibited lung carcinogenesis and tumor cell growth. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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