Anti-PDPN/ AGGRUS/ GP36 monoclonal antibody

Anti-PDPN/ AGGRUS/ GP36 antibody for FACS & in-vivo assay

Target products collectionGo to PDPN/PDPN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP1359-Ab-1/ GM-Tg-hg-MP1359-Ab-2Anti-Human PDPN monoclonal antibodyHuman
GM-Tg-rg-MP1359-Ab-1/ GM-Tg-rg-MP1359-Ab-2Anti-Rat PDPN monoclonal antibodyRat
GM-Tg-mg-MP1359-Ab-1/ GM-Tg-mg-MP1359-Ab-2Anti-Mouse PDPN monoclonal antibodyMouse
GM-Tg-cynog-MP1359-Ab-1/ GM-Tg-cynog-MP1359-Ab-2Anti-Cynomolgus/ Rhesus macaque PDPN monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP1359-Ab-1/ GM-Tg-felg-MP1359-Ab-2Anti-Feline PDPN monoclonal antibodyFeline
GM-Tg-cang-MP1359-Ab-1/ GM-Tg-cang-MP1359-Ab-2Anti-Canine PDPN monoclonal antibodyCanine
GM-Tg-bovg-MP1359-Ab-1/ GM-Tg-bovg-MP1359-Ab-2Anti-Bovine PDPN monoclonal antibodyBovine
GM-Tg-equg-MP1359-Ab-1/ GM-Tg-equg-MP1359-Ab-2Anti-Equine PDPN monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP1359-Ab-1/ GM-Tg-hg-MP1359-Ab-2; GM-Tg-rg-MP1359-Ab-1/ GM-Tg-rg-MP1359-Ab-2;
GM-Tg-mg-MP1359-Ab-1/ GM-Tg-mg-MP1359-Ab-2; GM-Tg-cynog-MP1359-Ab-1/ GM-Tg-cynog-MP1359-Ab-2;
GM-Tg-felg-MP1359-Ab-1/ GM-Tg-felg-MP1359-Ab-2; GM-Tg-cang-MP1359-Ab-1/ GM-Tg-cang-MP1359-Ab-2;
GM-Tg-bovg-MP1359-Ab-1/ GM-Tg-bovg-MP1359-Ab-2; GM-Tg-equg-MP1359-Ab-1/ GM-Tg-equg-MP1359-Ab-2
Products NameAnti-PDPN monoclonal antibody
Formatmab
Target NamePDPN
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PDPN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species PDPN/ AGGRUS/ GP36 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLP004978human PDPN Lentivirus plasmid
    ORF Viral VectorvGMLP004978human PDPN Lentivirus particle
    ORF Viral VectorpGMAD000490house mouse Pdpn Adenovirus plasmid
    ORF Viral VectorpGMLPm001042mouse Pdpn Lentivirus plasmid
    ORF Viral VectorpGMLPm003681mouse Pdpn Lentivirus plasmid
    ORF Viral VectorvGMAD000490house mouse Pdpn Adenovirus particle
    ORF Viral VectorvGMLPm001042mouse Pdpn Lentivirus particle
    ORF Viral VectorvGMLPm003681mouse Pdpn Lentivirus particle


    Target information

    Target IDGM-MP1359
    Target NamePDPN
    Gene ID10630,14726,54320,716250,403886,101081910,509732,102148273
    Gene Symbol and SynonymsAGGRUS,D2-40,E11,GP36,Gp38,GP40,HT1A-1,OTS-8,OTS8,PA2.26,PDPN,RANDAM-2,RTI40,T1-alpha,T1A,T1A-2,T1A2,T1alpha,TI1A
    Uniprot AccessionQ86YL7,Q64294,Q95152
    Uniprot Entry NamePDPN_HUMAN,PDPN_RAT,PDPN_CANLF
    Protein Sub-locationTransmembrane Protein
    Category
    DiseaseCancer
    Gene EnsemblENSG00000162493
    Target ClassificationTumor-associated antigen (TAA)

    The target: PDPN, gene name: PDPN, also named as AGGRUS, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, T1A-2, T1A2, TI1A. This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.