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Anti-PNOC/ N/OFQ/ NOP monoclonal antibody
Anti-PNOC/ N/OFQ/ NOP antibody for FACS & in-vivo assay
Go to PNOC/PNOC products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2561-Ab-1/ GM-Tg-hg-MP2561-Ab-2 | Anti-Human PNOC monoclonal antibody | Human |
| GM-Tg-rg-MP2561-Ab-1/ GM-Tg-rg-MP2561-Ab-2 | Anti-Rat PNOC monoclonal antibody | Rat |
| GM-Tg-mg-MP2561-Ab-1/ GM-Tg-mg-MP2561-Ab-2 | Anti-Mouse PNOC monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2561-Ab-1/ GM-Tg-cynog-MP2561-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PNOC monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2561-Ab-1/ GM-Tg-felg-MP2561-Ab-2 | Anti-Feline PNOC monoclonal antibody | Feline |
| GM-Tg-cang-MP2561-Ab-1/ GM-Tg-cang-MP2561-Ab-2 | Anti-Canine PNOC monoclonal antibody | Canine |
| GM-Tg-bovg-MP2561-Ab-1/ GM-Tg-bovg-MP2561-Ab-2 | Anti-Bovine PNOC monoclonal antibody | Bovine |
| GM-Tg-equg-MP2561-Ab-1/ GM-Tg-equg-MP2561-Ab-2 | Anti-Equine PNOC monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2561-Ab-1/ GM-Tg-hg-MP2561-Ab-2; GM-Tg-rg-MP2561-Ab-1/ GM-Tg-rg-MP2561-Ab-2; GM-Tg-mg-MP2561-Ab-1/ GM-Tg-mg-MP2561-Ab-2; GM-Tg-cynog-MP2561-Ab-1/ GM-Tg-cynog-MP2561-Ab-2; GM-Tg-felg-MP2561-Ab-1/ GM-Tg-felg-MP2561-Ab-2; GM-Tg-cang-MP2561-Ab-1/ GM-Tg-cang-MP2561-Ab-2; GM-Tg-bovg-MP2561-Ab-1/ GM-Tg-bovg-MP2561-Ab-2; GM-Tg-equg-MP2561-Ab-1/ GM-Tg-equg-MP2561-Ab-2 |
| Products Name | Anti-PNOC monoclonal antibody |
| Format | mab |
| Target Name | PNOC |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PNOC benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species PNOC/ N/OFQ/ NOP VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP003008 | human PNOC Lentivirus plasmid |
| ORF Viral Vector | vGMLP003008 | human PNOC Lentivirus particle |
| ORF Viral Vector | pGMLPm001322 | mouse Pnoc Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001322 | mouse Pnoc Lentivirus particle |
Target information
| Target ID | GM-MP2561 |
| Target Name | PNOC |
| Gene ID | 5368,18155,25516,713633,486095,101094754,281414,100061049 |
| Gene Symbol and Synonyms | N/OFQ,N23K,Nociceptin,NOP,Npnc1,OFQ,OFQ/N,PNOC,ppN/OFQ,PPNOC |
| Uniprot Accession | Q13519,Q62923,O62647 |
| Uniprot Entry Name | PNOC_HUMAN,PNOC_RAT,PNOC_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000168081 |
| Target Classification | N/A |
The target: PNOC, gene name: PNOC, also named as N/OFQ, NOP, OFQ, PPNOC, ppN/OFQ. This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include nociceptin, nocistatin, and orphanin FQ2 (OFQ2). Nociceptin, also known as orphanin FQ, is a 17-amino acid neuropeptide that binds to the nociceptin receptor to induce increased pain sensitivity, and may additionally regulate body temperature, learning and memory, and hunger. Another product of the encoded preproprotein, nocistatin, may inhibit the effects of nociceptin. [provided by RefSeq, Jul 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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