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Anti-AA™/ GOT2/ KAT4 monoclonal antibody
Anti-AA™/ GOT2/ KAT4 antibody for FACS & in-vivo assay
Go to GOT2/GOT2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2587-Ab-1/ GM-Tg-hg-MP2587-Ab-2 | Anti-Human GOT2 monoclonal antibody | Human |
| GM-Tg-rg-MP2587-Ab-1/ GM-Tg-rg-MP2587-Ab-2 | Anti-Rat GOT2 monoclonal antibody | Rat |
| GM-Tg-mg-MP2587-Ab-1/ GM-Tg-mg-MP2587-Ab-2 | Anti-Mouse GOT2 monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2587-Ab-1/ GM-Tg-cynog-MP2587-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GOT2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2587-Ab-1/ GM-Tg-felg-MP2587-Ab-2 | Anti-Feline GOT2 monoclonal antibody | Feline |
| GM-Tg-cang-MP2587-Ab-1/ GM-Tg-cang-MP2587-Ab-2 | Anti-Canine GOT2 monoclonal antibody | Canine |
| GM-Tg-bovg-MP2587-Ab-1/ GM-Tg-bovg-MP2587-Ab-2 | Anti-Bovine GOT2 monoclonal antibody | Bovine |
| GM-Tg-equg-MP2587-Ab-1/ GM-Tg-equg-MP2587-Ab-2 | Anti-Equine GOT2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2587-Ab-1/ GM-Tg-hg-MP2587-Ab-2; GM-Tg-rg-MP2587-Ab-1/ GM-Tg-rg-MP2587-Ab-2; GM-Tg-mg-MP2587-Ab-1/ GM-Tg-mg-MP2587-Ab-2; GM-Tg-cynog-MP2587-Ab-1/ GM-Tg-cynog-MP2587-Ab-2; GM-Tg-felg-MP2587-Ab-1/ GM-Tg-felg-MP2587-Ab-2; GM-Tg-cang-MP2587-Ab-1/ GM-Tg-cang-MP2587-Ab-2; GM-Tg-bovg-MP2587-Ab-1/ GM-Tg-bovg-MP2587-Ab-2; GM-Tg-equg-MP2587-Ab-1/ GM-Tg-equg-MP2587-Ab-2 |
| Products Name | Anti-GOT2 monoclonal antibody |
| Format | mab |
| Target Name | GOT2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GOT2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species AA™/ GOT2/ KAT4 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP002404 | human GOT2 Lentivirus plasmid |
| ORF Viral Vector | vGMLP002404 | human GOT2 Lentivirus particle |
| ORF Viral Vector | pGMLPm005333 | mouse Got2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005333 | mouse Got2 Lentivirus particle |
Target information
| Target ID | GM-MP2587 |
| Target Name | GOT2 |
| Gene ID | 2806,14719,25721,707896,478103,101090160,286886,100052607 |
| Gene Symbol and Synonyms | ASPATA,DEE82,FABP-1,FABP-pm,FABPpm,Got-2,GOT2,KAT4,KATIV,KYAT4,mAAT,mAspAT,mitAAT |
| Uniprot Accession | P00505,P00507,P12344,P08907 |
| Uniprot Entry Name | AA™_HUMAN,AA™_RAT,AA™_BOVIN,AA™_HORSE |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000125166 |
| Target Classification | N/A |
The target: GOT2, gene name: GOT2, also named as KAT4, KATIV, KYAT4, mitAAT. Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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