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Anti-PTHR/ PTHLH/ BDE2 functional antibody
Anti-PTHR/ PTHLH/ BDE2 functional antibody for cell culture, ELISA & in-vivo assay
Go to PTHLH/PTHLH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1230-Ab-1/ GM-Tg-hg-SE1230-Ab-2 | Anti-Human PTHLH monoclonal antibody | Human |
| GM-Tg-rg-SE1230-Ab-1/ GM-Tg-rg-SE1230-Ab-2 | Anti-Rat PTHLH monoclonal antibody | Rat |
| GM-Tg-mg-SE1230-Ab-1/ GM-Tg-mg-SE1230-Ab-2 | Anti-Mouse PTHLH monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1230-Ab-1/ GM-Tg-cynog-SE1230-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PTHLH monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1230-Ab-1/ GM-Tg-felg-SE1230-Ab-2 | Anti-Feline PTHLH monoclonal antibody | Feline |
| GM-Tg-cang-SE1230-Ab-1/ GM-Tg-cang-SE1230-Ab-2 | Anti-Canine PTHLH monoclonal antibody | Canine |
| GM-Tg-bovg-SE1230-Ab-1/ GM-Tg-bovg-SE1230-Ab-2 | Anti-Bovine PTHLH monoclonal antibody | Bovine |
| GM-Tg-equg-SE1230-Ab-1/ GM-Tg-equg-SE1230-Ab-2 | Anti-Equine PTHLH monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1230-Ab-1/ GM-Tg-hg-SE1230-Ab-2; GM-Tg-rg-SE1230-Ab-1/ GM-Tg-rg-SE1230-Ab-2; GM-Tg-mg-SE1230-Ab-1/ GM-Tg-mg-SE1230-Ab-2; GM-Tg-cynog-SE1230-Ab-1/ GM-Tg-cynog-SE1230-Ab-2; GM-Tg-felg-SE1230-Ab-1/ GM-Tg-felg-SE1230-Ab-2; GM-Tg-cang-SE1230-Ab-1/ GM-Tg-cang-SE1230-Ab-2; GM-Tg-bovg-SE1230-Ab-1/ GM-Tg-bovg-SE1230-Ab-2; GM-Tg-equg-SE1230-Ab-1/ GM-Tg-equg-SE1230-Ab-2 |
| Products Name | Anti-PTHLH monoclonal antibody |
| Format | mab |
| Target Name | PTHLH |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PTHLH benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1230-Ag-1 | Recombinant multi-species PTHR/ PTHLH/ BDE2 protein |
| ORF Viral Vector | pGMLP000529 | human PTHLH Lentivirus plasmid |
| ORF Viral Vector | pGMAP000211 | Human PTHLH Adenovirus plasmid |
| ORF Viral Vector | vGMAP000211 | Human PTHLH Adenovirus particle |
| ORF Viral Vector | vGMLP000529 | human PTHLH Lentivirus particle |
| ORF Viral Vector | pGMAAV000041 | mouse Pthlh AAV plasmid |
| ORF Viral Vector | vGMAAV000041 | mouse Pthlh AAV particle |
Target information
| Target ID | GM-SE1230 |
| Target Name | PTHLH |
| Gene ID | 5744,19227,24695,710295,403987,554222,286767,100033979 |
| Gene Symbol and Synonyms | BDE2,HHM,PLP,PTH-like,PTHLH,PTHR,PTHRP |
| Uniprot Accession | P12272,P13085,P52211,P58073,Q9GMB7 |
| Uniprot Entry Name | PTHR_HUMAN,PTHR_RAT,PTHR_CANLF,PTHR_BOVIN,PTHR_HORSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Lung cancer |
| Gene Ensembl | ENSG00000087494 |
| Target Classification | N/A |
The target: PTHLH, gene name: PTHLH, also named as BDE2, HHM, PLP, PTHR, PTHRP. The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone. [provided by RefSeq, Nov 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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