Anti-PTHR/ PTHLH/ BDE2 functional antibody

Anti-PTHR/ PTHLH/ BDE2 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to PTHLH/PTHLH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1230-Ab-1/ GM-Tg-hg-SE1230-Ab-2Anti-Human PTHLH monoclonal antibodyHuman
GM-Tg-rg-SE1230-Ab-1/ GM-Tg-rg-SE1230-Ab-2Anti-Rat PTHLH monoclonal antibodyRat
GM-Tg-mg-SE1230-Ab-1/ GM-Tg-mg-SE1230-Ab-2Anti-Mouse PTHLH monoclonal antibodyMouse
GM-Tg-cynog-SE1230-Ab-1/ GM-Tg-cynog-SE1230-Ab-2Anti-Cynomolgus/ Rhesus macaque PTHLH monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1230-Ab-1/ GM-Tg-felg-SE1230-Ab-2Anti-Feline PTHLH monoclonal antibodyFeline
GM-Tg-cang-SE1230-Ab-1/ GM-Tg-cang-SE1230-Ab-2Anti-Canine PTHLH monoclonal antibodyCanine
GM-Tg-bovg-SE1230-Ab-1/ GM-Tg-bovg-SE1230-Ab-2Anti-Bovine PTHLH monoclonal antibodyBovine
GM-Tg-equg-SE1230-Ab-1/ GM-Tg-equg-SE1230-Ab-2Anti-Equine PTHLH monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-SE1230-Ab-1/ GM-Tg-hg-SE1230-Ab-2; GM-Tg-rg-SE1230-Ab-1/ GM-Tg-rg-SE1230-Ab-2;
GM-Tg-mg-SE1230-Ab-1/ GM-Tg-mg-SE1230-Ab-2; GM-Tg-cynog-SE1230-Ab-1/ GM-Tg-cynog-SE1230-Ab-2;
GM-Tg-felg-SE1230-Ab-1/ GM-Tg-felg-SE1230-Ab-2; GM-Tg-cang-SE1230-Ab-1/ GM-Tg-cang-SE1230-Ab-2;
GM-Tg-bovg-SE1230-Ab-1/ GM-Tg-bovg-SE1230-Ab-2; GM-Tg-equg-SE1230-Ab-1/ GM-Tg-equg-SE1230-Ab-2
Products NameAnti-PTHLH monoclonal antibody
Formatmab
Target NamePTHLH
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PTHLH benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1230-Ag-1Recombinant multi-species PTHR/ PTHLH/ BDE2 protein
    ORF Viral VectorpGMLP000529human PTHLH Lentivirus plasmid
    ORF Viral VectorpGMAP000211Human PTHLH Adenovirus plasmid
    ORF Viral VectorvGMAP000211Human PTHLH Adenovirus particle
    ORF Viral VectorvGMLP000529human PTHLH Lentivirus particle
    ORF Viral VectorpGMAAV000041mouse Pthlh AAV plasmid
    ORF Viral VectorvGMAAV000041mouse Pthlh AAV particle


    Target information

    Target IDGM-SE1230
    Target NamePTHLH
    Gene ID5744,19227,24695,710295,403987,554222,286767,100033979
    Gene Symbol and SynonymsBDE2,HHM,PLP,PTH-like,PTHLH,PTHR,PTHRP
    Uniprot AccessionP12272,P13085,P52211,P58073,Q9GMB7
    Uniprot Entry NamePTHR_HUMAN,PTHR_RAT,PTHR_CANLF,PTHR_BOVIN,PTHR_HORSE
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Category
    DiseaseLung cancer
    Gene EnsemblENSG00000087494
    Target ClassificationN/A

    The target: PTHLH, gene name: PTHLH, also named as BDE2, HHM, PLP, PTHR, PTHRP. The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone. [provided by RefSeq, Nov 2013].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.