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Anti-THBG/ SERPINA7/ TBG functional antibody
Anti-THBG/ SERPINA7/ TBG functional antibody for cell culture, ELISA & in-vivo assay
Go to SERPINA7/SERPINA7 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1279-Ab-1/ GM-Tg-hg-SE1279-Ab-2 | Anti-Human SERPINA7 monoclonal antibody | Human |
| GM-Tg-rg-SE1279-Ab-1/ GM-Tg-rg-SE1279-Ab-2 | Anti-Rat SERPINA7 monoclonal antibody | Rat |
| GM-Tg-mg-SE1279-Ab-1/ GM-Tg-mg-SE1279-Ab-2 | Anti-Mouse SERPINA7 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1279-Ab-1/ GM-Tg-cynog-SE1279-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SERPINA7 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1279-Ab-1/ GM-Tg-felg-SE1279-Ab-2 | Anti-Feline SERPINA7 monoclonal antibody | Feline |
| GM-Tg-cang-SE1279-Ab-1/ GM-Tg-cang-SE1279-Ab-2 | Anti-Canine SERPINA7 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1279-Ab-1/ GM-Tg-bovg-SE1279-Ab-2 | Anti-Bovine SERPINA7 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1279-Ab-1/ GM-Tg-equg-SE1279-Ab-2 | Anti-Equine SERPINA7 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1279-Ab-1/ GM-Tg-hg-SE1279-Ab-2; GM-Tg-rg-SE1279-Ab-1/ GM-Tg-rg-SE1279-Ab-2; GM-Tg-mg-SE1279-Ab-1/ GM-Tg-mg-SE1279-Ab-2; GM-Tg-cynog-SE1279-Ab-1/ GM-Tg-cynog-SE1279-Ab-2; GM-Tg-felg-SE1279-Ab-1/ GM-Tg-felg-SE1279-Ab-2; GM-Tg-cang-SE1279-Ab-1/ GM-Tg-cang-SE1279-Ab-2; GM-Tg-bovg-SE1279-Ab-1/ GM-Tg-bovg-SE1279-Ab-2; GM-Tg-equg-SE1279-Ab-1/ GM-Tg-equg-SE1279-Ab-2 |
| Products Name | Anti-SERPINA7 monoclonal antibody |
| Format | mab |
| Target Name | SERPINA7 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Diagnostic target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SERPINA7 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1279-Ag-1 | Recombinant multi-species THBG/ SERPINA7/ TBG protein |
| ORF Viral Vector | vGMLP002278 | human SERPINA7 Lentivirus particle |
| ORF Viral Vector | pGMLP002278 | human SERPINA7 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001836 | mouse Serpina7 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001836 | mouse Serpina7 Lentivirus particle |
Target information
| Target ID | GM-SE1279 |
| Target Name | SERPINA7 |
| Gene ID | 6906,331535,81806,700439,481007,101100545,282518,100061538 |
| Gene Symbol and Synonyms | C730040N12Rik,SERPINA7,TBG,TBGQTL |
| Uniprot Accession | P05543,P35577,Q9TT36 |
| Uniprot Entry Name | THBG_HUMAN,THBG_RAT,THBG_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Diagnostics Biomarker |
| Disease | N/A |
| Gene Ensembl | ENSG00000123561 |
| Target Classification | N/A |
The target: SERPINA7, gene name: SERPINA7, also named as TBG, TBGQTL. There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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