Bovine p-tau212 and 214 antibody and antigen (recombinant protein)

Diagnostic anti-Bovine p-tau212 and 214 antibodies pairs and antigen for animal health (animal Bovines/Cattle Alzheimer Disease(AD)) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Target products collectionGo to Ruminants disease testing products collection >>


Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-BOV-p-tau212-214-Ag01Bovine p-tau212 and 214$3090.00
GMP-BOV-p-tau212-214-Ab01Anti-Bovine p-tau212 and 214 mouse monoclonal antibody (mAb)$3090.00
GMP-BOV-p-tau212-214-Ab02Anti-Bovine p-tau212 and 214 mouse monoclonal antibody (mAb)$3090.00
GMP-BOV-p-tau212-214-Ab03Anti-Bovine p-tau212 and 214 human monoclonal antibody (mAb)$3090.00
GMP-BOV-p-tau212-214-Ab04Anti-Bovine p-tau212 and 214 human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-BOV-p-tau212-214-Ag01
Product NameBovine p-tau212 and 214
Target/BiomarkerBovine p-tau212 and 214
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Bovine p-tau212 and 214 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in p-tau212 and 214 level test of animal Bovines/Cattle with Alzheimer Disease(AD).
TagHis
Reconized/Reactive SpecicsBovine p-tau212 and 214
Product descriptionRecombinant Bovine p-tau212 and 214 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-BOV-p-tau212-214-Ab01,GMP-BOV-p-tau212-214-Ab02
Target/BiomarkerBovine p-tau212 and 214
Product NameAnti-Bovine p-tau212 and 214 mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Bovine p-tau212 and 214 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bovine p-tau212 and 214 antibodies in Bovine p-tau212 and 214 level test of animal Bovines/Cattle with Alzheimer Disease(AD).
Product descriptionAnti-Bovine p-tau212 and 214 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bovine p-tau212 and 214 antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-BOV-p-tau212-214-Ab03,GMP-BOV-p-tau212-214-Ab04
Target/BiomarkerBovine p-tau212 and 214
Product NameAnti-Bovine p-tau212 and 214 human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Bovine p-tau212 and 214 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Bovine p-tau212 and 214 antibodies in Bovine p-tau212 and 214 level test of animal Bovines/Cattle with Alzheimer Disease(AD).
Product descriptionAnti-Bovine p-tau212 and 214 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    Bovine p-tau212 and p-tau214 represent a specific subset of tau proteins intricately linked to the neurological profile of cattle. These phosphorylated tau variants are predominantly localized within the central nervous system (CNS) of bovines, where they play a crucial role in maintaining the structural stability of neuronal microtubules.

    Under normal circumstances, tau proteins, including p-tau212 and p-tau214, are tasked with binding to microtubules and aiding in their assembly. This function ensures the proper functioning of neurons, including axonal transport and synaptic communication. The equilibrium in tau phosphorylation is delicate, and any disruption can have profound consequences.

    In neurodegenerative disorders, including tauopathies observed in cattle, tau proteins undergo abnormal phosphorylation. This post-translational modification results in tau proteins assuming atypical conformations, rendering them susceptible to aggregation. The aggregation of tau proteins culminates in the formation of neurofibrillary tangles within neurons. These tangles disrupt axonal transport, compromise synaptic function, and eventually lead to neuronal dysfunction and degeneration. The presence of elevated levels of p-tau212 and p-tau214 is indicative of these pathological processes and the potential emergence of cognitive and neurological deficits in affected cattle.



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