Histophilus somni antibody and antigen (recombinant protein)
Diagnostic anti-Histophilus somni antibodies pairs and antigen for animal health (animal Bovines/Cattle infectious disease septicemia, thromboembolic meningoencepahlitis (TEME), respiratory syndrome) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT
Go to Ruminants disease testing products collection >>
Product information
Catalog No. | Description | US $ Price (per mg) |
---|---|---|
GMP-VT-P079-Ag01 | Recombinant Histophilus somni protein | $3090.00 |
GMP-VT-P079-Ab01 | Anti-Histophilus somni mouse monoclonal antibody (mAb) | $3090.00 |
GMP-VT-P079-Ab02 | Anti-Histophilus somni mouse monoclonal antibody (mAb) | $3090.00 |
Size: 1mg | 10mg | 100mg
Product Description
Cat No. | GMP-VT-P079-Ag01 |
Product Name | Recombinant Histophilus somni protein |
Pathogen | Histophilus somni |
Expression platform | E.coli |
Isotypes | Recombinant Antigen |
Bioactivity validation | Anti-Histophilus somni antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in Histophilus somni level test of animal Bovines/Cattle infectious disease with septicemia, thromboembolic meningoencepahlitis (TEME), respiratory syndrome. |
Tag | His | Product description | Recombinant Histophilus somni proteinwas expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus. |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Cat No. | GMP-VT-P079-Ab01,GMP-VT-P079-Ab02 |
Pathogen | Histophilus somni |
Product Name | Anti-Histophilus somni mouse monoclonal antibody (mAb) |
Expression platform | CHO |
Isotypes | Mouse IgG |
Bioactivity validation | Recombinant Histophilus somni antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Histophilus somni antibodies in Histophilus somni level test of animal Bovines/Cattle infectious disease with septicemia, thromboembolic meningoencepahlitis (TEME), respiratory syndrome. |
Product description | Anti-Histophilus somni mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Histophilus somni antibodies./td> |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Validation Data
Click to get more Data / Case study about the product.
Pathogen
Histophilus somni is a serious pathogen that can cause multifaceted diseases in ruminants. It is important to understand the bacterium's characteristics and pathogenesis to effectively diagnose and treat infections.
The bacterium is a gram-negative, rod-shaped prokaryote that belongs to the family Pasteurellaceae. The hsf gene is one of the most significant virulence factors in Histophilus somni, coding for the Histophilus somni fibronectin binding protein (Hsf). The Hsf protein plays a critical role in facilitating the bacterium's invasion of host cells and evasion of the immune system. Other virulence factors include hemolysins, which contribute to the bacterium's ability to cause septicemia, and adhesins, which help the bacterium attach to host tissues.
Histophilus somni primarily infects domestic ruminants, such as cattle, sheep, and goats. Wild ruminants, such as bison and deer, can also be infected. The range of diseases caused by Histophilus somni includes respiratory infections, septicemia, myocarditis, thrombotic meningoencephalitis, arthritis, and reproductive disorders. Respiratory infections are the most common manifestation of Histophilus somni infections, causing pneumonia or bronchopneumonia. Septicemia can occur following respiratory infection or as a primary disease, leading to endotoxemia, disseminated intravascular coagulation, and death. Thrombotic meningoencephalitis is a neurological disorder that causes inflammation of the brain and spinal cord, and is often fatal.
A number of diagnostic methods are available for detecting Histophilus somni infections. These include bacterial culture, PCR, and ELISA. Bacterial culture is the gold standard for diagnosis, but it can be time-consuming and may not provide accurate results if the bacterium is not cultured under the proper conditions. PCR tests can rapidly detect Histophilus somni DNA in clinical samples, while ELISA tests detect antibodies to specific Histophilus somni proteins in serum samples.
Antibiotics are the primary treatment for Histophilus somni infections. The choice of antibiotic depends on the severity and location of infection, as well as the bacterial sensitivity profile. Macrolides, tetracyclines, and fluoroquinolones are often effective against Histophilus somni. In addition to antibiotics, supportive care such as intravenous fluids and anti-inflammatory medications may be necessary to manage clinical signs and prevent complications.
In conclusion, Histophilus somni is a significant pathogen that can cause a range of diseases in ruminants, with respiratory infections being the most common manifestation. The bacterium possesses several virulence factors, including the Hsf protein, that enable it to invade host cells and evade the immune system. Early diagnosis and prompt treatment with appropriate antibiotics are crucial for successful management of Histophilus somni infections.
About GDU
GDU helps global diagnostic partners in high quality of raw material discovery, development, and application. GDU believes in Protein&antibody Innovation for more reliable diagnostic solutions.