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Anti-IL1RA/ IL1RN/ DIRA monoclonal antibody
Anti-IL1RA/ IL1RN/ DIRA antibody for FACS & in-vivo assay
Go to IL1RN/IL1RN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-MP2544-Ab-1/ GM-Tg-hg-MP2544-Ab-2 | Anti-Human IL1RN monoclonal antibody | Human |
| GM-Tg-rg-MP2544-Ab-1/ GM-Tg-rg-MP2544-Ab-2 | Anti-Rat IL1RN monoclonal antibody | Rat |
| GM-Tg-mg-MP2544-Ab-1/ GM-Tg-mg-MP2544-Ab-2 | Anti-Mouse IL1RN monoclonal antibody | Mouse |
| GM-Tg-cynog-MP2544-Ab-1/ GM-Tg-cynog-MP2544-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL1RN monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-MP2544-Ab-1/ GM-Tg-felg-MP2544-Ab-2 | Anti-Feline IL1RN monoclonal antibody | Feline |
| GM-Tg-cang-MP2544-Ab-1/ GM-Tg-cang-MP2544-Ab-2 | Anti-Canine IL1RN monoclonal antibody | Canine |
| GM-Tg-bovg-MP2544-Ab-1/ GM-Tg-bovg-MP2544-Ab-2 | Anti-Bovine IL1RN monoclonal antibody | Bovine |
| GM-Tg-equg-MP2544-Ab-1/ GM-Tg-equg-MP2544-Ab-2 | Anti-Equine IL1RN monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-MP2544-Ab-1/ GM-Tg-hg-MP2544-Ab-2; GM-Tg-rg-MP2544-Ab-1/ GM-Tg-rg-MP2544-Ab-2; GM-Tg-mg-MP2544-Ab-1/ GM-Tg-mg-MP2544-Ab-2; GM-Tg-cynog-MP2544-Ab-1/ GM-Tg-cynog-MP2544-Ab-2; GM-Tg-felg-MP2544-Ab-1/ GM-Tg-felg-MP2544-Ab-2; GM-Tg-cang-MP2544-Ab-1/ GM-Tg-cang-MP2544-Ab-2; GM-Tg-bovg-MP2544-Ab-1/ GM-Tg-bovg-MP2544-Ab-2; GM-Tg-equg-MP2544-Ab-1/ GM-Tg-equg-MP2544-Ab-2 |
| Products Name | Anti-IL1RN monoclonal antibody |
| Format | mab |
| Target Name | IL1RN |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL1RN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species IL1RA/ IL1RN/ DIRA VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-MP2544-Ag-1 | interleukin 1 receptor antagonist (IL1RN) protein |
| ORF Viral Vector | pGMAP000045 | Human IL1RN Adenovirus plasmid |
| ORF Viral Vector | vGMAP000045 | Human IL1RN Adenovirus particle |
| ORF Viral Vector | pGMLP000397 | human IL1RN Lentivirus plasmid |
| ORF Viral Vector | vGMLP000397 | human IL1RN Lentivirus particle |
| ORF Viral Vector | pGMLV000054 | mouse Il1rn Lentivirus plasmid |
| ORF Viral Vector | vGMLV000054 | mouse Il1rn Lentivirus particle |
Target information
| Target ID | GM-MP2544 |
| Target Name | IL1RN |
| Gene ID | 3557,16181,60582,701658,281860,100034236 |
| Gene Symbol and Synonyms | DIRA,F630041P17Rik,ICIL-1RA,IL-1ra,IL-1ra3,IL-1RN,IL1F3,IL1RA,IL1RN,IRAP,MVCD4 |
| Uniprot Accession | P18510,P25086,Q9BEH0,O77482,O18999 |
| Uniprot Entry Name | IL1RA_HUMAN,IL1RA_RAT,IL1RA_CANLF,IL1RA_BOVIN,IL1RA_HORSE |
| Protein Sub-location | Transmembrane Protein |
| Category | Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000136689 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: IL1RN, gene name: IL1RN, also named as DIRA, ICIL-1RA, IL-1RN, IL-1ra, IL-1ra3, IL1F3, IL1RA, IRAP, MVCD4. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses, particularly in the acute phase of infection and inflammation. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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