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Anti-TIMP3/ HSMRK222/ K222 functional antibody
Anti-TIMP3/ HSMRK222/ K222 functional antibody for cell culture, ELISA & in-vivo assay
Go to TIMP3/TIMP3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1339-Ab-1/ GM-Tg-hg-SE1339-Ab-2 | Anti-Human TIMP3 monoclonal antibody | Human |
| GM-Tg-rg-SE1339-Ab-1/ GM-Tg-rg-SE1339-Ab-2 | Anti-Rat TIMP3 monoclonal antibody | Rat |
| GM-Tg-mg-SE1339-Ab-1/ GM-Tg-mg-SE1339-Ab-2 | Anti-Mouse TIMP3 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1339-Ab-1/ GM-Tg-cynog-SE1339-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TIMP3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1339-Ab-1/ GM-Tg-felg-SE1339-Ab-2 | Anti-Feline TIMP3 monoclonal antibody | Feline |
| GM-Tg-cang-SE1339-Ab-1/ GM-Tg-cang-SE1339-Ab-2 | Anti-Canine TIMP3 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1339-Ab-1/ GM-Tg-bovg-SE1339-Ab-2 | Anti-Bovine TIMP3 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1339-Ab-1/ GM-Tg-equg-SE1339-Ab-2 | Anti-Equine TIMP3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1339-Ab-1/ GM-Tg-hg-SE1339-Ab-2; GM-Tg-rg-SE1339-Ab-1/ GM-Tg-rg-SE1339-Ab-2; GM-Tg-mg-SE1339-Ab-1/ GM-Tg-mg-SE1339-Ab-2; GM-Tg-cynog-SE1339-Ab-1/ GM-Tg-cynog-SE1339-Ab-2; GM-Tg-felg-SE1339-Ab-1/ GM-Tg-felg-SE1339-Ab-2; GM-Tg-cang-SE1339-Ab-1/ GM-Tg-cang-SE1339-Ab-2; GM-Tg-bovg-SE1339-Ab-1/ GM-Tg-bovg-SE1339-Ab-2; GM-Tg-equg-SE1339-Ab-1/ GM-Tg-equg-SE1339-Ab-2 |
| Products Name | Anti-TIMP3 monoclonal antibody |
| Format | mab |
| Target Name | TIMP3 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TIMP3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1339-Ag-1 | Recombinant multi-species TIMP3/ HSMRK222/ K222 protein |
| ORF Viral Vector | vGMAP000031 | Human TIMP3 Adenovirus particle |
| ORF Viral Vector | vGMLP000407 | human TIMP3 Lentivirus particle |
| ORF Viral Vector | pGMLP000407 | human TIMP3 Lentivirus plasmid |
| ORF Viral Vector | pGMAP000031 | Human TIMP3 Adenovirus plasmid |
| ORF Viral Vector | pGMLPm003919 | mouse Timp3 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003919 | mouse Timp3 Lentivirus particle |
Target information
| Target ID | GM-SE1339 |
| Target Name | TIMP3 |
| Gene ID | 7078,21859,25358,574381,481289,101091215,282094,100033947 |
| Gene Symbol and Synonyms | HSMRK222,K222,K222TA2,SFD,Timp-3,TIMP3 |
| Uniprot Accession | P35625,P48032,Q5PXZ9,P79121,Q9TUL9 |
| Uniprot Entry Name | TIMP3_HUMAN,TIMP3_MACMU,TIMP3_RAT,TIMP3_BOVIN,TIMP3_HORSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Juvenile astrocytoma |
| Gene Ensembl | ENSG00000100234 |
| Target Classification | N/A |
The target: TIMP3, gene name: TIMP3, also named as HSMRK222, K222, K222TA2, SFD. This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
