Feline p-tau181 antibody and antigen (recombinant protein)

Diagnostic anti-Feline p-tau181 antibodies pairs and antigen for animal health (animal Cat/Feline Alzheimer Disease(AD)) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

Target products collectionGo to Companion Animal disease testing products collection >>


Product information

Catalog No.DescriptionUS $ Price (per mg)
GMP-FEL-p-tau181-Ag01Feline p-tau181$3090.00
GMP-FEL-p-tau181-Ab01Anti-Feline p-tau181 mouse monoclonal antibody (mAb)$3090.00
GMP-FEL-p-tau181-Ab02Anti-Feline p-tau181 mouse monoclonal antibody (mAb)$3090.00
GMP-FEL-p-tau181-Ab03Anti-Feline p-tau181 human monoclonal antibody (mAb)$3090.00
GMP-FEL-p-tau181-Ab04Anti-Feline p-tau181 human monoclonal antibody (mAb)$3090.00

Size： 1mg | 10mg | 100mg



Product Description

Cat No. GMP-FEL-p-tau181-Ag01
Product NameFeline p-tau181
Target/BiomarkerFeline p-tau181
Expression platformE.coli
IsotypesRecombinant Antigen
Bioactivity validationAnti-Feline p-tau181 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in p-tau181 level test of animal Cat/Feline with Alzheimer Disease(AD).
TagHis
Reconized/Reactive SpecicsFeline p-tau181
Product descriptionRecombinant Feline p-tau181 protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-FEL-p-tau181-Ab01,GMP-FEL-p-tau181-Ab02
Target/BiomarkerFeline p-tau181
Product NameAnti-Feline p-tau181 mouse monoclonal antibody (mAb)
Expression platformCHO
Isotypes Mouse IgG
Bioactivity validationRecombinant Feline p-tau181 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline p-tau181 antibodies in Feline p-tau181 level test of animal Cat/Feline with Alzheimer Disease(AD).
Product descriptionAnti-Feline p-tau181 mouse monoclonal antibody (mAb) is a mouse monoclonal antibody produced by CHO technology. The antibody is ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline p-tau181 antibodies.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Cat No.GMP-FEL-p-tau181-Ab03,GMP-FEL-p-tau181-Ab04
Target/BiomarkerFeline p-tau181
Product NameAnti-Feline p-tau181 human monoclonal antibody (mAb)
Expression platformCHO
IsotypesHuman lgG1
Bioactivity validationRecombinant Feline p-tau181 antigen binding, ELISA validated as capture antibody and detection antibody. Pair recommendation with other anti-Feline p-tau181 antibodies in Feline p-tau181 level test of animal Cat/Feline with Alzheimer Disease(AD).
Product descriptionAnti-Feline p-tau181 mouse monoclonal antibody (mAb) is a human monoclonal antibody produced by CHO. The antibody is ELISA validated as capture antibody and detection antibody pair.
PurityPurity: ≥95% (SDS-PAGE)
Application Paired antibody immunoassay validation in Sandwich ELISA, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays.
FormulationLyophilized from sterile PBS, PH 7.4
StorageStore at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


Reference




    Validation Data


    Click to get more Data / Case study about the product.



    Target/Biomarker Information


    Feline p-tau181, the phosphorylated Tau Protein 181 variant unique to cats, takes center stage in the intricate tapestry of feline neurobiology. At its core, it is a Tau protein that has undergone precise biochemical modification – phosphorylation – specifically at residue 181. Tau proteins, under normal circumstances, are the guardians of microtubule stability, ensuring the structural integrity of neuronal axons and enabling proper intracellular transport.

    However, when neurodegenerative processes unfold, the narrative shifts dramatically. Phosphorylation events can trigger the misfolding and aggregation of Tau proteins, and feline p-tau181 is no exception. It tends to aggregate and form neurofibrillary tangles (NFTs) within the neural tissues of afflicted cats.

    These NFTs, akin to those observed in human neurodegenerative diseases such as Alzheimer's, are a pathological signature of various feline neurodegenerative conditions. The accumulation of p-tau181 in NFTs contributes to progressive neuronal dysfunction, cognitive decline, and motor disturbances, as evident in conditions like feline cognitive dysfunction syndrome (FCDS) and specific encephalopathies.



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    GDU

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