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Blog | Gene Therapy Technical Articles

Oncolytic virus immunotherapy (HSV, oncolytic adenovirus) and cancer therapy

Oncolytic virotherapy is a novel therapeutic modality utilizing oncolytic viruses (such as herpes simplex-, pox-, parvo-, or adenoviruses), which selectively replicate in cancer cells, to directly induce tumor cell lysis or indirectly reactivate human immune system to mediate tumor destruction.

CAR-T immunotherapy and cancer therapy

Chimeric antigen receptor (CAR)-modified T cells (CAR-T) are T cells genetically engineered to express CAR, which can specifically recognize their target antigen via the scFv binding domain of CAR, resulting in T cell activation to specifically target and destroy tumor cells.

TCR-T immunotherapy and cancer therapy

T-cell receptor (TCR)–engineered T-cell therapy (TCR-T) is one potentially powerful treatment that utilizes genetically modified natural T cells to specifically target tumors and destroy tumors with greater potentials.

CAR-NK immunotherapy and cancer therapy

Although CAR-T has been applied in clinic, quite a lot of side effects, such as off-target, cytokine release syndrome (CRS) etc., pose a great restriction in their further clinical application.

Immuno-oncology cell therapy

In the past several decades, great progress has been made in the field of anti-tumor therapy, but there are also multiple strategies for tumors to evade the recognition and efficient suppression by the immune system. Therefore, a variety of immunotherapeutic targets and strategies have been developed to reactivate and reorganize the human immune system, such as CAR-T, TCR-T, CAR-NK, DC-CIK, oncolytic virus and so on.

Stem Cell Therapy

Cell therapy based on stem cells is a kind of regenerative medicine with great potential for the treatment of diseases via the differentiation ability or the paracrine effects of stem cells as well as their derivatives.

Genetic re-engineering cell therapy

Besides the immune-oncology therapy and stem cell derived therapy, gene replacement therapy via lentivirus, adenovirus and adenovirus associated virus (AAV) as well as genetic engineered strategies via CRISPR, ZLN, TALEN have been widely applied in the field of cell therapy.

How much do you trust Dr. Google?

Women experiencing signs of breast cancer vary in how they value, use, and trust 'Dr. Google' when making sense of their symptoms, a new study reports.

Weather Forecasting

Weather forecasting is the application of current technology and science to predict the state of the atmosphere for a future time and a given location.

Amino Acid Structure Chart and Reference Table

Amino acids are the backbone of peptides and proteins. All amino acids contain both amino and carboxylic acids, and in certain cases, side chains.

Amino Acid Codes

Amino acids are the backbone of peptides and proteins. All amino acids contain both amino and carboxylic acids, and in certain cases, side chains.